Magister en Neurocencias UACh
CNS Remyelination and the Neurovascular Niche: From the Regenerative Mechanism to the Therapy.
Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS) and affects over 2 million people worldwide. Current treatments target primarily the immune system, reducing the formation of inflammatory lesions in the CNS, however with only temporary and limited success. In response to myelin damage, spontaneous remyelination takes place through the activation of CNS-resident stem and progenitor cells. Although myelin regeneration occurs at early MS stages, the level and quality are apparently insufficient for a sustained endogenous functional repair. Furthermore, ageing reduces remyelination efficacy and represents a crucial factor for MS progression. Therefore, it results encouraging to explore unkown cellular and molecular cues that regulate remyelination. In this regards, there are more evidence indicating that the neurovascular niche (including blood-derived elements) plays a crucial role in neuroregeneration. Indeed, our previous studies indicate that the neurovascular niche robustly responds to demyelination and regulate CNS-resident stem / progenitor cell function. Thus, we aim to determine how the neurovascular niche contributes to CNS remyelination and to develop new molecular/cellular therapies for the treatment of demyelinating diseases, such as MS.
- Kazanis I, Feichtner M, Lange S, Rotheneichner P, Hainzl S, Öller M, Schallmoser K, Rohde E, Reitsamer HA, Couillard-Despres S, Bauer H-C, Franklin RJM, Aigner L, Rivera FJ. Lesion-Induced Accumulation of Platelets Promotes Survival of Adult Neural Stem / Progenitor Cells. Experimental Neurology 2015; 269:75-89. Original Article (PMID: 25819103).
- Lange S, Trost A, Tempfer H, Bauer HC, Bauer H, Rohde E, Reitsamer HA, Franklin RJM, Aigner L, Rivera FJ. Brain Pericyte Plasticity as a Potential Drug Target in CNS Repair. Drug Discovery Today 2013; 18(9-10):456-63. Review Article (PMID: 23266366).
- Steffenhagen C, Dechant F-X, Furtner T, Weidner N, Kury P, Aigner L, Rivera FJ. Mesenchymal Stem Cells Prime Proliferating Adult Neural Progenitors Towards an Oligodendrocyte Fate. Stem Cells and Development 2012; 21(11):1838-1851. Original Article (PMID: 22074360).
- Rivera FJ, Couillard-Despres S, Pedre-Villareal X, Ploetz S, Lois C, Bogdahn U, Aigner L. Mesenchymal Stem Cells Instruct Oligodendrogenic Fate Decision on Adult Neural Stem Cells. Stem Cells 2006; 24:2209–2219. Original Article (PMID: 16763198).
Laboratory of Stem Cells and Neuroregeneration
Institute of Anatomy, Histology and Pathology
Facultad de Medicina
Espacio CISNe (Ex-embriología)
Universidad Austral de Chile
Campus Isla Teja S/N
Valdivia, 511-0566, Chile